2015年8月7日

免疫检查点蛋白- B7-CD28超家族

B7家族由结构相关的细胞表面蛋白配体组成，它们与淋巴细胞上调节免疫反应的受体结合。T和B淋巴细胞的激活是由细胞表面、抗原特异性T细胞或B细胞受体的参与引起的，但由B7配体同时传递的附加信号决定最终的免疫应答。这些“共刺激”或“共抑制”信号由B7配体通过淋巴细胞上的受体CD28家族传递，也导致了白介素产生的调节。b7家族成员与共刺激受体相互作用增强免疫反应，与共抑制受体相互作用减弱免疫反应。

目前已知的B7家族有9个成员:B7.1 (CD80)， B7.2 (CD86)，诱导共刺激配体(ICOS- l)，程序性死亡-1配体(PD-L1)，程序性死亡-2配体(PD-L2)， B7- h3, B7- h4, VISTA (B7- h5)和B7- h7，以及CD28家族的4个已知成员:CD28, CTLA-4 (CD152)， ICOS, PD-1。B7-CD28超家族在调节免疫反应方面的重要性可以从一些成员在免疫缺陷和自身免疫疾病发展中的作用中得到证明。B7配体传递的信号的调控在自身免疫、炎症和癌症的治疗中显示出了潜力。

CD28(人):Fc(人)(rec.) (CHI-HF-210CD28)

CD28(鼠标):Fc(鼠标)(rec.) (CHI-MF-110CD28)

CD152 [CTLA-4](人):Fc(人)(rec.) (CHI-HF-210A4)

CD152 [CTLA-4](人):Fc(人)(rec.)(非溶性)(CHI-HF-220A4)

CD152 [CTLA-4](人):Fc(小鼠)(rec.) (CHI-HF-211A4)

CD152 [CTLA-4] (mouse):Fc (mouse) (rec.) (CHI-MF-110A4)

CD152 [CTLA-4](小鼠):Fc(小鼠)(rec.)(非溶性)(CHI-MF-120A4)

CD278 [ICOS](人):Fc(人)(rec.) (CHI-HF-210ICOS)

CD278 [ICOS](人):Fc(人)(rec.)(非溶性)(CHI-HF-220ICOS)

CD278 [ICOS](人):Fc(小鼠)(rec.) (CHI-HF-211ICOS)

CD278 [ICOS](鼠标):Fc(鼠标)(rec.) (CHI-MF-110ICOS)

CD279 [PD-1](人)(recc .) (CHI-HF-200PD1)

CD279 [PD-1](人):Fc(人)(rec.) (CHI-HF-210PD1)

CD279 [PD-1](人):Fc(人)(rec.)(非溶性)(CHI-HF-220PD1)

CD279 [PD-1](人):Fc(小鼠)(rec.) (CHI-HF-211PD1)

CD279 [PD-1] (mouse):Fc (mouse) (rec.) (CHI-MF-110PD1)

CD80(人):Fc(人)(rec.) (CHI-HF-210CD80)

CD80(人):Fc(小鼠)(rec.) (CHI-HF-211CD80)

CD80(鼠标):Fc(鼠标)(rec.) (CHI-MF-110CD80)

CD86(人):Fc(人)(rec.) (CHI-HF-210CD86)

CD86(人):Fc(小鼠)(rec.) (CHI-HF-211CD86)

CD86(老鼠):Fc(老鼠)(rec.) (CHI-MF-110CD86)

CD273 [PD-L2](人):Fc(人)(rec.) (CHI-HF-210PDL2)

CD273 [PD-L2](人):Fc(人)(rec.)(非溶性)(CHI-HF-220PDL2)

CD273 [PD-L2](人):Fc(小鼠)(rec.) (CHI-HF-211PDL2)

CD273 [PD-L2] (mouse):Fc (mouse) (rec.) (CHI-MF-110PDL2)

CD274 [B7-H1/PD-L1](人)(rec.) (CHI-HF-200PDL1)

CD274 [B7-H1/PD-L1](人):Fc(人)(rec.) (CHI-HF-210PDL1)

CD274 [B7-H1/PD-L1](人):Fc(人)(rec.)(非溶性)(CHI-HF-220PDL1)

CD274 [B7-H1/PD-L1](人):Fc(小鼠)(rec.) (CHI-HF-211PDL1)

CD274 [B7-H1/PD-L1](小鼠):Fc(小鼠)(rec.) (CHI-MF-110PDL1)

CD274 [B7-H1/PD-L1](小鼠):Fc(小鼠)(rec.)(非溶性)(CHI-MF-120PDL1)

CD275 [B7-H2](人)(rec.) (His) (CHI-HF-201B7H2)

CD275 [B7-H2](人):Fc(人)(rec.) (CHI-HF-210B7H2)

CD275 [B7-H2](人):Fc(人)(rec.)(非溶性)(CHI-HF-220B7H2)

CD275 [B7-H2](人):Fc(小鼠)(rec.) (CHI-HF-211B7H2)

CD275 [B7-H2] (mouse):Fc (mouse) (rec.) (CHI-MF-110B7H2)

CD275 [B7-H2](小鼠):Fc(小鼠)(rec.)(非溶性)(CHI-MF-120B7H2)

CD276 [B7-H3](人)(rec.) (CHI-HF-200B7H3)

CD276 [B7-H3](人):Fc(人)(rec.) (CHI-HF-210B7H3)

CD276 [B7-H3](人):Fc(小鼠)(rec.) (CHI-HF-211B7H3)

CD276 [B7-H3](小鼠):Fc(小鼠)(rec.) (CHI-MF-110B7H3)

B7-H3(4Ig) [B7-H3b](人)(rec.) (His) (CHI-HF-201B7H3B)

B7-H3(4Ig) [B7-H3b](人):Fc(小鼠)(rec.) (CHI-HF-211B7H3B)

B7-H4(人)(rec.) (CHI-HF-200B7H4)

B7-H4(人)(rec.) (His) (CHI-HF-201B7H4)

B7-H4(人):Fc(人)(rec.) (CHI-HF-210B7H4)

B7-H4(人):Fc(小鼠)(rec.) (CHI-HF-211B7H4)

B7-H4(人):Fc(兔)(rec.) (CHI-HF-212B7H4)

B7-H4(鼠标):Fc(鼠标)(rec.) (CHI-MF-110B7H4)

B7-H6(人):Fc(小鼠)(rec.) (CHI-HF-211B7H6)

其他免疫检查点蛋白

CD27(人)(rec.) (His) (CHI-HR-200CD27)

CD27(人):Fc(人)(rec.) (CHI-HF-210CD27)

CD40L [CD154](人):Fc(人)(rec.) (CHI-HF-210CD40L)

CD134 [OX40](人)(rec.) (His) (CHI-HR-200CD134)

CD134 [OX40](人):Fc(人)(rec.) (CHI-HF-210CD134)

CD134 [OX40](人):Fc(小鼠)(rec.) (CHI-HF-211CD134)

CD134 [OX40](小鼠):Fc(人)(rec.) (CHI-MF-111CD134)

CD137(人)(rec.) (His) (CHI-HR-200CD137)

CD137(人):Fc(人)(rec.) (CHI-HF-210CD137)

CD137(人):Fc(小鼠)(rec.) (CHI-HF-211CD137)

CD272 [BTLA](人):Fc(人)(rec.) (CHI-HF-210CD272)

CD272 [BTLA](人):Fc(小鼠)(rec.) (CHI-HF-211CD272)

LAG-3(人):Fc(人)(rec.) (CHI-HF-210LAG3)

CD40(人):Fc(人)(rec.) (CHI-HF-210CD40)

CD200(人):Fc(人)(rec.)(非溶性)(CHI-HF-220CD200)

CD200(小鼠):Fc(小鼠)(rec.)(非溶性)(CHI-MF-120CD200)

CD252 [OX40L](人)(rec.) (His) (CHI-HF-201CD252)

CD252 [OX40L](人):Fc(小鼠)(rec.) (CHI-HF-211CD252)